The Role of Proneurotrophins in Apoptotic Signaling in Rat Brain Neurons
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چکیده
OF THE THESIS The Role of Proneurotrophins in Apoptotic Signaling in Rat Brain Neurons
منابع مشابه
ProNGF induces PTEN via p75NTR to suppress Trk-mediated survival signaling in brain neurons.
Proneurotrophins and mature neurotrophins activate different signaling pathways with distinct effects on their target cells: proneurotrophins can induce apoptotic signaling via p75(NTR), whereas mature neurotrophins activate Trk receptors to influence survival and differentiation. Here, we demonstrate that the PTEN (phosphatase and tensin homolog deleted on chromosome 10) phosphatase represents...
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Proneurotrophins bind with high affinity to p75 neurotrophin receptor (p75NTR) and lack the capacity to bind Trk receptors, suggesting that proneurotrophins can elicit apoptosis via p75NTR even in cells expressing survival-promoting Trk receptors. In the CNS, basal forebrain (BF) neurons are particularly vulnerable to degeneration in Alzheimer's disease, and are among the few populations of bra...
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تاریخ انتشار 2009